dWinlock is a portable, easy to use program (trial version, but fully functional, limited only by a warning message) and allows you to disable certain functions and key combinations of windows.
dWinlock offers the following functions:
Disabling keystrokes such as Ctrl+Alt+Del, Win+E, Win key, mouse buttons, keyboard mouse key or any key that you specify.
It can also hide or replace the desktop elements like desktop, taskbar, start menu, shutdown button, etc.
Moreover, you can hide dWinlock and can be enabled using a hotkey (default Ctrl+Alt+W) and can be password protected it.
Besides, all options can be activated or deactivated during runtime. No reboot is required to apply changes. dWinloack Works with Windows7, Vista, XP and 98.