Here is an application called VT Hash Check that enable you quickly check the MD5 checksum of a given file against the checksum database of VirusTotal.com.
The application adds a context menu item to windows explore. Just right click any application and select ‘Check File Hash to send the checksum of that file to http://www.virustotal.com. If the checksum matches a file already scanned by VirusTotal.com then the results of 0/42 anti-virus scanners are shown.
By default it will only check MD5 hash. There is an option to use the SHA1 hash of a file. If you prefer for SHA1 to be the default, create a file called "usesha1" (sans quotes) in the installation directory (by default: C:\Program Files\Boredom Software\VT Hash Check)
You can download VT Hash Check from developer's page